To identify the target genes of Evi-1 in hematopoietic stem cells (HSCs), we carried out genome-wide transcriptional analysis using wild-type and Evi-1-deleted HSCs.
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells.
Sex, Age
View SamplesMist1+CD24hi cells and Mist1+CD24lo cells in mouse small intestine were separatedly sorted, and RNAs were isolated.
No associated publication
Specimen part
View SamplesCells located at the invasive front and in the tumor mass of mouse cervical squamous cell carcinomas were isolated by laser microdissection from hematoxylin-stained HPV/E2 sections. 7 months old HPV/E2 mice treated with oestrogen develop invasive cervical squamous cell carcinomas. This model recapitulates human invasive cervical neoplasias.
Inflammatory Cytokines Induce Podoplanin Expression at the Tumor Invasive Front.
Specimen part
View SamplesIRF3 is one of the most critical transcription factor in down stream of pattern recognition receptors (such as toll-like receptor and RIG-I-like receptor) signalling pathway. IRF3 is known to induce the expression of type I IFN gene upon virus infection.
No associated publication
Specimen part, Treatment
View SamplesTAZ-deficient mice have the abnormalities in the lung development. We expect the comparison of the gene expression profiles of TAZ-deficient and wild-type lungs would reveal the underlying mechanisms.
Transcriptional coactivator with PDZ-binding motif is essential for normal alveolarization in mice.
No sample metadata fields
View SamplesOsteosarcoma (OS) is the malignant bone tumor with a high tendency to metastasize to the lung, where the molecular mechanisms are unclear. The mouse OS cell line LM8 has been isolated originally from the Dunn OS cell line by in vivo selection as a subline with a high metastatic potential to the lung.
Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcoma.
Cell line
View SamplesThis SuperSeries is composed of the SubSeries listed below.
DNA methylation profiling of embryonic stem cell differentiation into the three germ layers.
Sex, Specimen part
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice.
Sex, Age, Specimen part
View SamplesAquaporin-11 (AQP11), a new member of the aquaporin family, is localized in the endoplasmic reticulum (ER). Aqp11/ mice neonatally suffer from polycystic kidneys derived from the proximal tubule. Its onset is proceeded by the vacuolization of ER. However, the mechanism for the formation of vacuoles and the development of cysts remain to be clarified. Here, we show that Aqp11/ mice and polycystic kidney disease animals share a common pathogenic mechanism of cyst formation.
Aquaporin-11 knockout mice and polycystic kidney disease animals share a common mechanism of cyst formation.
Sex, Age, Specimen part
View SamplesWe compared the gene expressions of the intestine, liver and spleen tissues between mice at 4 months of age and mice at 28 months of age. We used microarrays to examine the age-related changes of gene expressions of the jejunum, ileum, distal colon, liver and spleen in mice. Abbreviations used: C, 28-month-old mice; Y, 4-month-old mice.
Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice.
Sex, Age, Specimen part
View Samples