Description

We aimed to define epithelial-specific genes in the kidney. In the developing mouse kidney at E12.5 epithelial cells are restricted to the ureteric bud, while mesenchymal cells surrounding the ureteric bud are non-epithelial. The mouse renal epithelial cell line mIMCD-3 was used to represent kidney epithelia in vitro. Gene expression was analyzed using Affymetrix microarrays in ureteric bud stalks, ureteric bud tips, and mIMCD-3 cells and compared to metanephric mesenchyme.

Publication Title

The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex.

Alternate Accession IDs

E-GEOD-24295

Sample Metadata Fields

Specimen part, Cell line