Description

MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone marrow cells.

Publication Title

MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.

Alternate Accession IDs

E-GEOD-25911

Sample Metadata Fields

Specimen part