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accession-icon GSE29458
Expression data from PDGF driven mouse tumors
  • organism-icon Mus musculus
  • sample-icon 23 Downloadable Samples
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Description

Background

Publication Title

Glioblastoma models reveal the connection between adult glial progenitors and the proneural phenotype.

Alternate Accession IDs

E-GEOD-29458

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Specimen part

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accession-icon GSE53225
Expression data from miR-92 over-expressing R26MER/MER mouse embryonic fibroblast (MEFs)
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
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Description

miR-92 enhances c-Myc induced apoptosis. In the R26MER/MER mouse embryonic fibroblasts (MEFs), a switchable variant of Myc, MycERT2, was knocked into the genomic region downstream of the constitutive Rosa26 promoter, allowing acute activation of c-Myc by 4-OHT-induced nuclear translocation. This in vitro system nicely recapitulates c-Myc-induced apoptosis, as activated MycERT2 induces strong p53-dependent apoptosis in response to serum starvation. Enforced miR-92 expression in three independent R26MER/MER MEF lines significantly enhanced Myc-induced apoptosis.

Publication Title

A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis.

Alternate Accession IDs

E-GEOD-53225

Sample Metadata Fields

Specimen part

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