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accession-icon GSE85240
Gene expression changes in stimulated and unstimulated Foxp1-deficient B cells.
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon

Description

Foxp1 is expressed throughout B cell development, but the physiological functions in mature B lymphocytes are unknown. We therefore evaluated differential gene expression in Foxp1-deficient B cells, with or

Publication Title

Foxp1 controls mature B cell survival and the development of follicular and B-1 B cells.

Alternate Accession IDs

E-GEOD-85240

Sample Metadata Fields

Specimen part

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accession-icon GSE17989
Influence of T and B lymphocytes on the antigen presentation capacities of splenic conventional dendritic cells
  • organism-icon Mus musculus
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon

Description

The goal of this project was to characterize DCs from lymphopenic mice, like RAG (recombination activated gene) deficient mice and to examine the influence of mature B and T cells on the antigen presenting ability of splenic cDCs. We demonstrate how cellular cross-talk can shape the character and function of cDCs. Lymphopenic conditions, where splenic cDCs have to develop and differentiate, drastically change their character and their ability to cross-present soluble antigen.

Publication Title

Immunoglobulins drive terminal maturation of splenic dendritic cells.

Alternate Accession IDs

E-GEOD-17989

Sample Metadata Fields

Sex, Age, Specimen part

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