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accession-icon GSE31561
Transcriptional analysis of organ-specific toxicity induced by a panPPAR agonist in mice: Identification of organ-specific toxicity biomarkers
  • organism-icon Mus musculus
  • sample-icon 36 Downloadable Samples
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Description

In this study, we aim to identify candidate biomarkers which may be useful as surrogate indicators of toxicity for pre-clinical development of panPPAR-agonist drug candidates. Gene expression microarray, histopathology and clinical chemistry data were generated from liver, heart, kidney and skeletal muscles of three groups of mice administered with three different dosages of an experimental pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist, PPM-201, for 14 days. The histopathology and clinical chemistry data were compared with the gene expression analysis and candidate biomarker genes were identified.

Publication Title

Simultaneous non-negative matrix factorization for multiple large scale gene expression datasets in toxicology.

Alternate Accession IDs

E-GEOD-31561

Sample Metadata Fields

Specimen part, Treatment

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accession-icon GSE38074
Scaling proprioceptor gene transcription by retrograde NT3 signaling
  • organism-icon Mus musculus
  • sample-icon 31 Downloadable Samples
  • Technology Badge Icon

Description

Transcriptional analysis of identified DRG subpopulations.

Publication Title

Scaling proprioceptor gene transcription by retrograde NT3 signaling.

Alternate Accession IDs

E-GEOD-38074

Sample Metadata Fields

Specimen part

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