TBR1 is a forebrain specific T-box transcription factor. Tbr1-/- mice have been characterized by defective axonal projections from cerebral cortex and abnormal neuronal migration of cerebral cortex and amygdala.
Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality.
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View SamplesThis study compared gene expression in murine bcr-abl positive acute lymphoblastic leukemia cells in vivo in allogeneic BMT recipients compared to syngneneic BMT recipients.
Differential gene expression in acute lymphoblastic leukemia cells surviving allogeneic transplant.
Specimen part
View SamplesWe used microarrays to detail the role of Polycomb proteins including Ezh2 and Eed in maintaining ES cell identity and executing pluripotency.
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
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View SamplesThis represents an unbiased evaluation of the transcriptional response in the prefrontal cortex and hippocampus areas in the Df(16)A/+ mice, a mouse model of human 22q11 microdeletion syndrome. These mice were generated by chromosomal engineering and carry a microdeltion of ~1.3Mb in the mouse locus syntenic to the human 22q11.1
Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model.
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View SamplesThis SuperSeries is composed of the SubSeries listed below.
Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation.
Sex, Specimen part
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