Description

The transcription co-factor FOG1 interacts with the chromatin remodeling complex NuRD to mediate gene activation and gene repression during hematopoiesis. We have generated mice with a targeted mutation in the endogenous Fog1 locus that results in an N-ternimal mutation in FOG1 that disrupts the interaction with NuRD.

Publication Title

Pleiotropic platelet defects in mice with disrupted FOG1-NuRD interaction.

Alternate Accession IDs

E-GEOD-29975

Sample Metadata Fields

Specimen part