Role of loss of Pofut1 expression on self-renewal and differentiation of adult neural progenitor cells

Reduced NotchR signaling has been implicated in the reduced division and differentiation of stem cells in a number of tissues. The Protein-O-fucosyltransferase 1 gene (Pofut1) encodes a glycosyltransferase that O-fucosylates EGF-repeat-containing proteins, including Notch Receptors (NotchRs), and absence of Pofut1 glycosylation on NotchRs inhibits ligand-induced NotchR signaling.

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