Morphine effects on striatal transcriptome in four inbred mouse strains

Chronic opiate use produces molecular and cellular adaptations in the nervous system, leading to tolerance, physical dependence and addiction. Genome-wide comparison of morphine-induced changes in brain transcription of mouse strains with different opioid-related phenotypes provides an opportunity to discover the relationship between gene expression and behavioral response to the drug.

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Korostynski M, Piechota M, Kaminska D, Solecki W, Przewlocki R