The impact of P53 loss on transcriptome changes following loss of Apc in the intestine

BACKGROUND: p53 is an important tumor suppressor with a known role in the later stages of colorectal cancer, but its relevance to the early stages of neoplastic initiation remains somewhat unclear. Although p53-dependent regulation of Wnt signalling activity is known to occur, the importance of these regulatory mechanisms during the early stages of intestinal neoplasia has not been demonstrated.

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Reed KR, Meniel VS, Marsh V, Cole A, Sansom OJ, Clarke AR