Insm1 cooperates with Neurod1 and Foxa2 to maintain mature pancreatic -cell function (Expression data from islets of control and Insm1 conditional deleted adult pancreatic islets)

The zinc finger factor Insm1 is known to regulate differentiation of pancreatic cells during development, Here we show that Insm1 is essential for the maintenance of functionally mature pancreatic cells in mice.

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Jia S, Ivanov A, Blasevic D, Müller T, Purfürst B, Sun W, Chen W, Poy MN, Rajewsky N, Birchmeier C