Gene expression in aortic roots of wild type versus klotho-deficient mice at 6 weeks of age

Klotho-deficient mice develop aortic valve annulus calcification by 6 weeks of age. Understanding the molecular basis by which aortic valve calcification is initiated will help define potential molecular targets which may be inhibited to reduce or prevent aortic valve calcification.

6

Wirrig EE, Gomez MV, Hinton RB, Yutzey KE