Gene regulation in macrophages from irradiated tumors

Tumors engender an environment dominated by M2 differentiated tumor macrophages that support tumor invasion, metastases and escape from immune control. In this study, we demonstrate that following radiation therapy of tumors in mice there is an influx of tumor macrophages that polarize towards wound repair and immune suppression.

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Crittenden MR, Cottam B, Savage T, Nguyen C, Newell P, Gough MJ