Stem Cell Antigen-1 (Sca-1) Regulates Mammary Tumor Development and Cell Migration

Stem cell antigen-1 (Sca-1 or Ly6A) is a member of the Ly6 family of glycosyl phostidylinositol (GPI)-anchored cell surface proteins. To determine the potential mechanisms by which Sca-1 regulates cell migration, adhesion, and tumor development; we performed an Affymetrix mouse genome 430A 2.0 array on cDNA comparing shLuc and shSca-1 from cells grown in vitro.

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Batts TD, Machado HL, Zhang Y, Creighton CJ, Li Y, Rosen JM