Expression data from WT, HEB-KO and E2A-KO LY6D- CLP cells

The E-protein transcription factors E2A and HEB play important roles at several stages of hematopoiesis. However, the exact mechanism for theire action and the main targets in the LY6D negative common lymphoid progentior (CLP) compartment remains unknown. By adressing this question, we will gain important infromation regarding the early events leading to B-cell specification.

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Welinder E, Mansson R, Mercer EM, Bryder D, Sigvardsson M, Murre C