Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation

Dorsomorphin is a small molecule inhibitor of type I bone morphogenic protein receptors (BMPRs). We have found that dorsomorphin affects a wide range of T cell function. In order to obtain the bigger picture of the effects of DM in T cell activation. transcriptomic analysis was performed using mouse primary CD25-CD4+ T cells with either DM (4 M) or vehicle in the presence or absence of stimulation by anti-CD3 and -CD28 antibodies.

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Yoshioka Y, Ono M, Osaki M, Konishi I, Sakaguchi S