Involvement of 4E-BP1 in the protection induced by HDLs on pancreatic beta cells

High-density lipoproteins (HDLs) protect pancreatic cells against apoptosis. This property might be related to the increased risk to develop diabetes in patients with low HDL blood levels. However, the mechanisms by which HDLs protect cells are poorly characterized. Here we use a transcriptomic approach to identify genes differentially modulated by HDLs in cells subjected to apoptotic stimuli.

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Pétremand J, Bulat N, Butty AC, Poussin C, Rütti S, Au K, Ghosh S, Mooser V, Thorens B, Yang JY, Widmann C, Waeber G