Expression data from WT and KO of Myc in innate lymphoid cell 2 (ILC2) in mice

Group-2 innate lymphoid cells (ILC2) serve crucial function in allergy and asthma. Activated ILC2 rapidly proliferate and secret large amounts of type-2 cytokines, such as IL-5 and IL-13. Mechanisms underlying still remain ambiguous. Here we report that Myc is required for ILC2 proliferation and activation in allergic airway inflammation. Inhibition of Myc impair the ILC2 proliferation in vivo and prevented ILC2-mediated airway hyperresponsiveness in vivo.

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Ye L, Pan J, Liang M, Pasha MA, Shen X, D'Souza SS, Fung ITH, Wang Y, Patel G, Tang DD, Yang Q