Efficient Array-based Identification of Novel Cardiac Genes through Differentiation of Mouse ESCs

Cardiac disease accounts for the largest proportion of adult mortality and morbidity in the industrialized world. However, progress toward improved clinical treatments is hampered by an incomplete understanding of the genetic programs controlling early cardiogenesis. To better understand this process, we set out to identify genes whose expression is enriched within early cardiac fated populations, obtaining the transcriptional signatures of mouse embryonic stem cells (mESCs) differentiating along a cardiac path.

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Miller RA, Christoforou N, Pevsner J, McCallion AS, Gearhart JD