Comparison of the transcriptional profiles of the retinal pigmental epithelium/choroid from young and old mice

To characterize underlying changes in the retinal pigment epithelium (RPE)/choroid with age, we produced gene expression profiles for the RPE/choroid and compared the transcriptional profiles of the RPE/choroid from young and old mice. The changes in the aged RPE/choroid suggest that the tissue has become immunologically active. Such phenotypic changes in the normal aged RPE/choroid may provide a background for the development of age-related macular degeneration.

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Chen H, Liu B, Lukas TJ, Neufeld AH