Genome wide expression analysis in AtT-20 cells following Dnmt1 knockdown

Efficient and sustained knockdown of DNMT1 transcript and protein was achieved using a consecutive transfection protocol in the mouse pituitary adenoma cell line, AtT-20. Genome wide microarray analysis identified 91 transcripts that were significantly differentially expressed relative to cells treated with a non-targeting control.

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Dudley KJ, Revill K, Whitby P, Clayton RN, Farrell WE