Expression data from calvaria of 10-day-old 13del-tg transgenic mice displaying bone overgrowth.

The ectopic expression of a Col10a1-13del transgene in osteocytes induced ER stress, compromising their differentiation and expression of Sclerostin, resulting in generalized bone overgrowth resembling human crainodiaphyseal chondrodysplasia (CCD).

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Chan WCW, Tsang KY, Cheng YW, Ng VCW, Chik H, Tan ZJ, Boot-Handford R, Boyde A, Cheung KMC, Cheah KSE, Chan D