Filters
Organism
Technology
Platforms
Description
In order to gain insight into the molecular pathogenesis of the myelodysplastic syndromes (MDS), we performed global gene expression profiling and pathway analysis on the hematopoietic stem cells (HSC) of 183 MDS patients as compared with the HSC of 17 healthy controls. The most significantly deregu ...See More
Publication Title
Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells.
Alternate Accession IDs
E-GEOD-19429Sample Metadata Fields
Specimen part, Disease
Description
We aimed to determine the impact of the common mutations on the transcriptome in myelodysplastic syndromes (MDS). We linked genomic data with gene expression microarray data and we deconvoluted the expression of genes into contributions stemming from each genetic and cytogenetic alteration, providin ...See More
Publication Title
Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes.
Alternate Accession IDs
E-GEOD-58831Sample Metadata Fields
Specimen part, Disease
Description
In order to gain insight into the poorly understood pathophysiology of the myelodysplastic syndromes (MDS), we have determined the gene expression profiles of the CD34+ cells of 55 MDS patients using the Affymetrix GeneChip U133 Plus2.0 platform
Publication Title
Gene expression profiles of CD34+ cells in myelodysplastic syndromes: involvement of interferon-stimulated genes and correlation to FAB subtype and karyotype.
Alternate Accession IDs
E-GEOD-4619Sample Metadata Fields
No sample metadata fields
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming.
Alternate Accession IDs
E-GEOD-110164Sample Metadata Fields
Specimen part
Description
Epiblast cells in the early post-implantation stage mammalian embryo undergo a transition described as lineage priming before cell fate allocation, but signaling pathways acting upstream remain ill defined. Genetic studies demonstrate that Smad2/3 double-mutant mouse embryos die shortly after implan ...See More
Publication Title
Combinatorial Smad2/3 Activities Downstream of Nodal Signaling Maintain Embryonic/Extra-Embryonic Cell Identities during Lineage Priming.
Alternate Accession IDs
E-GEOD-110058Sample Metadata Fields
Specimen part
Description
The response of cells to hypoxia is characterised by co-ordinated regulation of many genes. Studies of the regulation of the expression of many of these genes by oxygen has implicated a role for the heterodimeric transcription factor hypoxia inducible factor (HIF). The mechanism of oxygen sensing wh ...See More
Publication Title
Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.
Alternate Accession IDs
E-GEOD-3188Sample Metadata Fields
No sample metadata fields
Description
Gene expression analysis of early thymic progenitors and thymus seeding progenitors
Publication Title
The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential.
Alternate Accession IDs
E-GEOD-29382Sample Metadata Fields
Sex, Age, Specimen part, Disease
Description
Inducible nitric oxide synthase (iNOS) plays a crucial role in controlling growth of mycobacteria, presumed to be via nitric oxide (NO) mediated killing. However, NOS enzymes can also signal through NO-independent pathways, and production of NO by NOS requires the cofactor tetrahydrobiopterin (BH4). ...See More
Publication Title
No associated publication
Alternate Accession IDs
E-GEOD-107543Sample Metadata Fields
Specimen part
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Lipid-induced epigenomic changes in human macrophages identify a coronary artery disease-associated variant that regulates PPAP2B Expression through Altered C/EBP-beta binding.
Alternate Accession IDs
E-GEOD-54975Sample Metadata Fields
Sex, Specimen part, Treatment
Description
16 replication error proficient (RER-/MSI-) and 14 replication error deficient (RER+/MSI+) colorectal cancer cell lines
Publication Title
Replication error deficient and proficient colorectal cancer gene expression differences caused by 3'UTR polyT sequence deletions.
Alternate Accession IDs
E-GEOD-24795Sample Metadata Fields
Cell line