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Description
Psoriasis is a chronic inflammatory skin disease of unknown etiology. Although macrophages and dendritic cells (DCs) have been proposed to drive the psoriatic cascade, their largely overlapping phenotype hampered studying their respective role. Topical application of Imiquimod, a Toll-like receptor ...See More
Publication Title
Dynamics and Transcriptomics of Skin Dendritic Cells and Macrophages in an Imiquimod-Induced, Biphasic Mouse Model of Psoriasis.
Alternate Accession IDs
E-GEOD-65309Sample Metadata Fields
Specimen part, Treatment
Description
Analysis of stratified epidermal cultures treated with IL-1a, IL-1F5, IL-1F6, IL-1F8 and IL-1F9 to determine the effects of these cytokines at 24h. Results provide insight into the role of IL-1 family cytokines in the pathogenesis of psoriasis.
Publication Title
IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.
Alternate Accession IDs
E-GEOD-25400Sample Metadata Fields
Specimen part, Treatment
Description
Development of a suitable mouse model would facilitate the investigation of pathomechanisms underlying human psoriasis and would also assist in development of therapeutic treatments. However, while many psoriasis mouse models have been proposed, no single model recapitulates all features of the hu ...See More
Publication Title
Genome-wide expression profiling of five mouse models identifies similarities and differences with human psoriasis.
Alternate Accession IDs
E-GEOD-27628Sample Metadata Fields
Specimen part
Description
Skin conventional dendritic cells (cDC) exist as two distinct subsets, cDC1 and cDC2, which maintain the balance of immunity to pathogens and tolerance to self and microbiota. Here we examined the roles of dermal cDC1 and cDC2 during bacterial infection, notably Propionibacterium acnes (P. acnes). c ...See More
Publication Title
A Subset of Type I Conventional Dendritic Cells Controls Cutaneous Bacterial Infections through VEGFα-Mediated Recruitment of Neutrophils.
Alternate Accession IDs
GSE129738Sample Metadata Fields
Specimen part, Treatment, Subject
Description
Drosophila melanogaster expresses three classes of small RNAs, which are classified according to their mechanisms of biogenesis. MicroRNAs are ~22-23-nt, ubiquitously expressed small RNAs that are sequentially processed from hairpin-like precursors by Drosha/Pasha and Dcr-1/Loquacious complexes. Mic ...See More
Publication Title
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform.
Alternate Accession IDs
GSE17171Sample Metadata Fields
Cell line, Subject
Description
Mind-body practices that elicit the relaxation response (RR) have been used worldwide for millennia to prevent and treat disease. The RR is believed to be the counterpart to stress response and is characterized by decreased oxygen consumption, increased exhaled nitric oxide, and reduced psychologica ...See More
Publication Title
Genomic counter-stress changes induced by the relaxation response.
Alternate Accession IDs
E-GEOD-10041Sample Metadata Fields
No sample metadata fields
Description
Hyperglycemic memory is part of the pathogenesis of diabetic retinopathy. We established a novel mouse model of intermediate-term hyperglycemic memory and demonstrated that changes in gene expression and microvascular damage in the neurovascular unit of the diabetic retina persist after euglycemic r ...See More
Publication Title
Hyperglycaemic memory affects the neurovascular unit of the retina in a diabetic mouse model.
Alternate Accession IDs
E-GEOD-87433Sample Metadata Fields
Specimen part, Disease
Description
The signaling pathways orchestrating both the evolution and development of language in the human brain remain unknown. To date, the transcription factor FOXP2 is the only gene implicated in Mendelian forms of human speech and language dysfunction1,2. It has been proposed, that the amino acid compo ...See More
Publication Title
Human-specific transcriptional regulation of CNS development genes by FOXP2.
Alternate Accession IDs
E-GEOD-18142Sample Metadata Fields
Specimen part, Cell line
Description
A case of transcriptional gene silencing, originally observed in tetraploid Arabidopsis plants, created an epiallele resistant to many mutations or inhibitor treatments that activate other suppressed genes. This raised the question about the molecular basis of this extreme stability.
Publication Title
Cooperation of multiple chromatin modifications can generate unanticipated stability of epigenetic States in Arabidopsis.
Alternate Accession IDs
E-GEOD-17496Sample Metadata Fields
Specimen part
Description
Hematopoietic stem cells (HSCs) are identified by their ability to sustain prolonged blood cell production in vivo, although recent evidence suggests that durable self-renewal (DSR) is shared by HSC subtypes with distinct self-perpetuating differentiation programs. Net expansions of DSR-HSCs occur i ...See More
Publication Title
Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal.
Alternate Accession IDs
E-GEOD-57220Sample Metadata Fields
Specimen part