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Description
The intestinal epithelium constitutes a crucial defense to the potentially life-threatening effects of gut microbiota. However, due to a complex underlying vasculature, hypoperfusion and resultant tissue ischemia pose a particular risk to function and integrity of the epithelium. The small ubiquitin ...See More
Publication Title
Ubc9 overexpression and SUMO1 deficiency blunt inflammation after intestinal ischemia/reperfusion.
Alternate Accession IDs
E-GEOD-96733Sample Metadata Fields
Treatment
Description
Cellular differentiation requires both activation of target cell programs and repression of non-target cell programs. Transcriptional repressors such as RE1-silencing transcription factor (REST) and Hairy/Enhancer of Split (Hes) repress neuronal genes in non-neuronal cells. However, it is unknown wh ...See More
Publication Title
A Myt1 family transcription factor defines neuronal fate by repressing non-neuronal genes.
Alternate Accession IDs
GSE125694Sample Metadata Fields
Specimen part, Cell line, Treatment, Subject
Description
We sorted approx. 10000 neurons per sample from day one adult worms. We collected two wildtype samples and three thoc-5(wy822) mutant samples. Overall design: RNAseq of FACS-sorted C.elegans neurons from wildtype and thoc-5(wy822) mutant animals.
Publication Title
The THO Complex Coordinates Transcripts for Synapse Development and Dopamine Neuron Survival.
Alternate Accession IDs
GSE102300Sample Metadata Fields
Specimen part, Subject
Description
Microarray analyses for the identification of differences in gene expression patterns have increased our understanding of the molecular genetic events in colorectal cancer.
Publication Title
A molecular signature for the prediction of recurrence in colorectal cancer.
Alternate Accession IDs
E-GEOD-64857Sample Metadata Fields
Sex
Description
Various pluripotent stem (PS) cells can be isolated from early developing embryos in mouse. Among these, two kinds of PS cells were isolated from mouse blastocysts: conventional embryonic stem (ES) cells with domed morphology that are maintained with LIF and BMP for self-renewal, and FAB-ES cells w ...See More
Publication Title
The heterogeneity and dynamic equilibrium of rat embryonic stem cells.
Alternate Accession IDs
E-GEOD-19820Sample Metadata Fields
Specimen part
Description
Damage-associated molecular pattern (DAMP) molecules S100A8 and S100A9 with well-known functions in inflammation, tumor growth and metastasis. It has been found to have promote tumor cell proliferation activity at low concentration . However, the mechanism underlying this remains unclear. In the cur ...See More
Publication Title
Inflammation-induced S100A8 activates Id3 and promotes colorectal tumorigenesis.
Alternate Accession IDs
E-GEOD-53735Sample Metadata Fields
Cell line
Description
YAP knockdown in HUVEC elicits proliferation and cell cycle preogression defects. YAP deficient cells caused arrest in G1 and defects in S-phase entry. The microarray analysis was conducted to identify potential YAP targets that are involved in HUVEC cell cycle regulation
Publication Title
YAP regulates S-phase entry in endothelial cells.
Alternate Accession IDs
E-GEOD-61989Sample Metadata Fields
Specimen part, Treatment
Description
Dgcr8 and Dicer are both important components of the microRNA biogenesis pathway while Dicer is also implicated in biogenesis of other types of small RNAs such as siRNAs and mirtrons. Here we performed microarray analysis of WT, Dgcr8 and Dicer knockout ES cells to identify mRNAs differentially regu ...See More
Publication Title
Genomic analysis suggests that mRNA destabilization by the microprocessor is specialized for the auto-regulation of Dgcr8.
Alternate Accession IDs
E-GEOD-16923Sample Metadata Fields
Specimen part
Description
Super-enhancers (SEs) are large clusters of transcriptional enhancers that are co-occupied by multiple lineage specific transcription factors driving expression of genes that define cell identity. In embryonic stem cells (ESCs), SEs are highly enriched for Oct4, Sox2, and Nanog in the enhanceosome a ...See More
Publication Title
Tex10 Coordinates Epigenetic Control of Super-Enhancer Activity in Pluripotency and Reprogramming.
Alternate Accession IDs
GSE66734Sample Metadata Fields
No sample metadata fields
Description
Gene expression changes in response to aging, hyperoxia, hydrogen peroxide, ionizing radiation, and heat stress were compared using microarrays. While aging shared features with each stress, aging was more similar to the stresses most associated with oxidative stress (hydrogen peroxide, hyperoxia, ...See More
Publication Title
Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster.
Alternate Accession IDs
E-GEOD-42255Sample Metadata Fields
Sex, Age