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Description
To understand the underlying cause and mechanisms of embryonic lethality observed in combined loss of E2f7 and E2f8, we compared global gene expression profiles of wild type, germline deleted and sox2-Cre/Cyp19-Cre deleted embryos and placentas.
Publication Title
Atypical E2F repressors and activators coordinate placental development.
Alternate Accession IDs
E-GEOD-30488Sample Metadata Fields
Specimen part
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
Alternate Accession IDs
E-GEOD-56009Sample Metadata Fields
Specimen part
Description
Combined ablation of Myc and E2f1-3 results in disruption of crypt-villus integrity in the small intestine due to a S-G2 cell cycle blockade.
Publication Title
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
Alternate Accession IDs
E-GEOD-56006Sample Metadata Fields
Specimen part
Description
Loss of Myc corrects abrrant transcription in Rb KO villi, while these genetic manipulation does not lead to major gene expression changes in crypts.
Publication Title
Redeployment of Myc and E2f1-3 drives Rb-deficient cell cycles.
Alternate Accession IDs
E-GEOD-56007Sample Metadata Fields
Specimen part
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Canonical and atypical E2Fs regulate the mammalian endocycle.
Alternate Accession IDs
E-GEOD-32355Sample Metadata Fields
Age, Specimen part
Description
To understand the underlying cause and mechanisms of changes in hepatocyte ploidy upon Albumin-Cre mediated deletion of E2f7&8 and Mx1-Cre mediated deletion of E2f1,2&3, we analysed global gene expression of 6 weeks and 2 months liver tissues.
Publication Title
Canonical and atypical E2Fs regulate the mammalian endocycle.
Alternate Accession IDs
E-GEOD-32354Sample Metadata Fields
Age, Specimen part
Description
Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel recurrent mutations while at the same time highlighting the genetic heterogeneity of the disease. These observations suggest that an extraordinarily large number of combinations of mutations can contrib ...See More
Publication Title
Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target.
Alternate Accession IDs
GSE71800Sample Metadata Fields
No sample metadata fields
Description
Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel recurrent mutations while at the same time highlighting the genetic heterogeneity of the disease. These observations suggest that an extraordinarily large number of combinations of mutations can contrib ...See More
Publication Title
Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target.
Alternate Accession IDs
GSE71840Sample Metadata Fields
No sample metadata fields
Description
Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel recurrent mutations while at the same time highlighting the genetic heterogeneity of the disease. These observations suggest that an extraordinarily large number of combinations of mutations can contrib ...See More
Publication Title
Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target.
Alternate Accession IDs
GSE71686Sample Metadata Fields
No sample metadata fields
Description
Next generation DNA sequencing of acute myeloid leukemia (AML) patient samples has revealed novel recurrent mutations while at the same time highlighting the genetic heterogeneity of the disease. These observations suggest that an extraordinarily large number of combinations of mutations can contrib ...See More
Publication Title
Modeling human MLL-AF9 translocated acute myeloid leukemia from single donors reveals RET as a potential therapeutic target.
Alternate Accession IDs
GSE71689Sample Metadata Fields
No sample metadata fields