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Description
Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dep ...See More
Publication Title
Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1.
Alternate Accession IDs
E-GEOD-19796Sample Metadata Fields
Specimen part
Description
The division rate of hematopoietic stem cells (HSCs) are promoted by estradiol. To identify the mechanism by which estradiol regulates HSCs, we performed gene expresssion profiling of HSCs isolated from mice of both sexes treated with either control vehicle (oil) or estradiol for one week.
Publication Title
Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy.
Alternate Accession IDs
E-GEOD-52711Sample Metadata Fields
Sex, Specimen part
Description
Fus is the gene for a member of the FET family of RNA-binding proteins often involved in chromosomal translocations to generate oncogenic fusion genes in human cancers. Fus participates in multiple cellular functions, including RNA processing and transport, transcriptional regulation, and genome int ...See More
Publication Title
FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells.
Alternate Accession IDs
E-GEOD-18853Sample Metadata Fields
Specimen part
Description
Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dep ...See More
Publication Title
Lethal myelofibrosis induced by Bmi1-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes.
Alternate Accession IDs
E-GEOD-31086Sample Metadata Fields
Specimen part
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells.
Alternate Accession IDs
E-GEOD-27787Sample Metadata Fields
Specimen part
Description
Each fraction of mouse hematopoietic cells was purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and its gene expression was analyzed.
Publication Title
Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells.
Alternate Accession IDs
E-GEOD-27786Sample Metadata Fields
Specimen part
Description
Mouse CD34(-)KSL hematopoietic stem cells and CD34(+)KSL multipotent progenitors were purified by cell sorting from bone marrow of 8-week-old C57BL/6 mice, and their gene expression was analyzed.
Publication Title
Forced expression of the histone demethylase Fbxl10 maintains self-renewing hematopoietic stem cells.
Alternate Accession IDs
E-GEOD-27785Sample Metadata Fields
Specimen part
Description
The B1 SOX transcription factors SOX1/2/3/19 have been implicated in various processes of early embryogenesis. However, their regulatory functions in stages from the blastula to early neurula remain largely unknown, primarily because loss-of-function studies have not been informative to date. In our ...See More
Publication Title
B1 SOX coordinate cell specification with patterning and morphogenesis in the early zebrafish embryo.
Alternate Accession IDs
E-GEOD-18830Sample Metadata Fields
Specimen part
Description
Pericytes confer vascular stability in the retina, and the loss of pericytes can cause the blood-retina barrier breakdown seen in diabetic retinopathy. To identify endothelial-specific genes expressed in pericyte-deprived retinal vessels, we purified genetically labeled endothelial cells from Tie2-G ...See More
Publication Title
Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown.
Alternate Accession IDs
E-GEOD-86819Sample Metadata Fields
Specimen part
Description
Infection with non-cytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial lipopolysaccharide (LPS) at the level of whole-t ...See More
Publication Title
Global transcriptomic profiling of bovine endometrial immune response in vitro. I. Effect of lipopolysaccharide on innate immunity.
Alternate Accession IDs
E-GEOD-71696Sample Metadata Fields
Sex, Treatment