Filters
Organism
Technology
Platforms
Description
To better understand the mechanistic basis of aging and its relationship with retinal degeneration, we examined gene expression changes in aging rod photoreceptors. Rod photoreceptor cell death is a feature of normal retinal aging and is accelerated in many retinal degenerative diseases, including A ...See More
Publication Title
Distinct signature of altered homeostasis in aging rod photoreceptors: implications for retinal diseases.
Alternate Accession IDs
E-GEOD-22317Sample Metadata Fields
Age, Specimen part
Description
The study aims to define gene expression changes associated with mithramycin treatment of Ewing Sarcoma cell lines.
Publication Title
Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.
Alternate Accession IDs
E-GEOD-25127Sample Metadata Fields
Cell line, Treatment
Description
This dataset contains Affymetrix Mouse Genome 430 2.0 Array data obtained from K7M2 cells over-expressing ezrinT567A and the wild-type
Publication Title
Dysregulation of ezrin phosphorylation prevents metastasis and alters cellular metabolism in osteosarcoma.
Alternate Accession IDs
E-GEOD-33897Sample Metadata Fields
Cell line
Description
Determination of gene expression changes in hindlimb muscle (gastrocnemius/soleus) of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112.
Publication Title
Dissection of temporal gene expression signatures of affected and spared muscle groups in dystrophin-deficient (mdx) mice.
Alternate Accession IDs
E-GEOD-1025Sample Metadata Fields
No sample metadata fields
Description
Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 14, 28, 56, and 112 days. 3 independent replicates/age/strain.
Publication Title
Dissection of temporal gene expression signatures of affected and spared muscle groups in dystrophin-deficient (mdx) mice.
Alternate Accession IDs
E-GEOD-1008Sample Metadata Fields
No sample metadata fields
Description
Rhesus monkey extraocular muscle. Data set includes: (a) whole medial and lateral rectus muscle and (b) global and orbital muscle layers separately microdissected using a Leica LSM. All samples were expression profiled here using the Affymetrix human U133 A&B arrays. Data form part of publication ...See More
Publication Title
Genome-wide transcriptional profiles are consistent with functional specialization of the extraocular muscle layers.
Alternate Accession IDs
E-GEOD-907Sample Metadata Fields
No sample metadata fields
Description
Staphylococcus aureus enterotoxins cause debilitating systemic inflammatory responses, but how they spread systemically and trigger cascading inflammation is unclear. Here, we showed in mice that after inhalation, Staphylococcus aureus enterotoxin A rapidly entered the bloodstream and induced T cell ...See More
Publication Title
TNF and CD28 Signaling Play Unique but Complementary Roles in the Systemic Recruitment of Innate Immune Cells after Staphylococcus aureus Enterotoxin A Inhalation.
Alternate Accession IDs
GSE76190Sample Metadata Fields
Specimen part, Cell line, Subject
Description
Rod and cone photoreceptors in mammalian retina are generated from common pool(s) of neuroepithelial progenitors. NRL, CRX and NR2E3 are key transcriptional regulators that control photoreceptor differentiation. Mutations in NR2E3, a rod-specific orphan nuclear receptor, lead to loss of rods, incr ...See More
Publication Title
In vivo function of the orphan nuclear receptor NR2E3 in establishing photoreceptor identity during mammalian retinal development.
Alternate Accession IDs
E-GEOD-5338Sample Metadata Fields
Sex, Specimen part
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Distinctive morphological and gene/protein expression signatures during myogenesis in novel cell lines from extraocular and hindlimb muscle.
Alternate Accession IDs
E-GEOD-4463Sample Metadata Fields
No sample metadata fields
Description
Determination of gene expression changes in extraocular muscle of mdx (dystrophin-deficient) mice at postnatal ages 7, 14, 23, 28, 56, and 112 days. 3 independent replicates/age/strain. Data form part of publication: Human Molecular Genetics 13:257-269, 2004.
Publication Title
Temporal gene expression profiling of dystrophin-deficient (mdx) mouse diaphragm identifies conserved and muscle group-specific mechanisms in the pathogenesis of muscular dystrophy.
Alternate Accession IDs
E-GEOD-1026Sample Metadata Fields
No sample metadata fields