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Description
A prevalent hypothesis for the cell-to-cell coordination of the phenomena of early development is that a defined mixture of different mRNA species at specific abundances in each cell determines fate and behavior. With this dataset we explore this hypothesis by quantifying the abundance of every mRNA ...See More
Publication Title
A Transcriptional Lineage of the Early C. elegans Embryo.
Alternate Accession IDs
GSE77944Sample Metadata Fields
Specimen part, Subject
Description
In order to obtain a global picture regarding regulation of p53 in liver cells we used HepG2 hepatoma cells.We created two isogenic sub-cultures of HepG2 cells with altered expression of p53.
Publication Title
Chemotherapeutic agents induce the expression and activity of their clearing enzyme CYP3A4 by activating p53.
Alternate Accession IDs
E-GEOD-30137Sample Metadata Fields
Specimen part, Cell line
Description
Effect of the overexpression of the oncogenic form of the Vav2 protein in the NIH3T3 cell line under serum deprivation conditions. oncovav2-transformed NIH3T3 cells grown in serum-deprived medium (Vav2SD) are compared to the parental NIH3T3 controls under the same growth conditions (ContSD). Vav2SD ...See More
Publication Title
Microarray analysis of gene expression with age in individual nematodes.
Alternate Accession IDs
NoneSample Metadata Fields
Cell line
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression.
Alternate Accession IDs
E-GEOD-64496Sample Metadata Fields
Specimen part, Cell line
Description
The transcriptional activiy of GATA1s was compared to GATA1 through gene expression analysis in a cell line model with both erythroid and megakaryocyte differentiation.
Publication Title
Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression.
Alternate Accession IDs
E-GEOD-64494Sample Metadata Fields
Specimen part, Cell line
marsh-affy-mouse-232749
Description
Malformations of cortical development are the underlying eitiology of many cases of Mental Retardation and Epilepsy. Subtle, below the resolution of current MRI, cortical dysplasias are probably involved in many cases of MR, Epilepsy and Autism for which no diagnosis can currently be made. Therefo ...See More
Publication Title
Identification of Arx transcriptional targets in the developing basal forebrain.
Alternate Accession IDs
E-GEOD-5817Sample Metadata Fields
No sample metadata fields
Description
Arx is a paired-box homeodomain transcription factor and the vertebrate ortholog to the Drosophila aristaless (al) gene. Mutations in Arx are associated with a variety of human diseases, including X-linked infantile spasm syndrome (OMIM: 308350), X-linked myoclonic epilepsy with mental retardation ...See More
Publication Title
Identification of Arx transcriptional targets in the developing basal forebrain.
Alternate Accession IDs
E-GEOD-12609Sample Metadata Fields
No sample metadata fields
Description
Recently, a frequent chromosomal aberration fusing Androgen regulated TMPRSS2 promoter and the ERG gene (T/ERG) was discovered in prostate cancer. Several studies demonstrated cooperation between the T/ERG and other defective pathways in cancer progression however, the biological mechanism by which ...See More
Publication Title
TMPRSS2/ERG promotes epithelial to mesenchymal transition through the ZEB1/ZEB2 axis in a prostate cancer model.
Alternate Accession IDs
E-GEOD-22010Sample Metadata Fields
Specimen part, Cell line
Description
The effect of drugs, disease and other perturbations on mRNA levels are studied using gene expression microarrays or RNA-seq, with the goal of understanding molecular effects arising from the perturbation. Previous comparisons of reproducibility across laboratories have been limited in scale and fo ...See More
Publication Title
Assessing Concordance of Drug-Induced Transcriptional Response in Rodent Liver and Cultured Hepatocytes.
Alternate Accession IDs
E-GEOD-74903Sample Metadata Fields
Sex, Specimen part
Description
Leaf development has been monitored chiefly by following anatomical markers. Analysis of transcriptome dynamics during leaf maturation revealed multiple expression patterns that rise or fall with age or that display age specific peaks. These were used to formulate a digital differentiation index (DD ...See More
Publication Title
A protracted and dynamic maturation schedule underlies Arabidopsis leaf development.
Alternate Accession IDs
E-GEOD-12691Sample Metadata Fields
No sample metadata fields