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Description
Hearts of Myh6-MeCP2 transgenic mice and wildtype littermates were rapidly dissected and flash frozen.
Publication Title
Adrenergic Repression of the Epigenetic Reader MeCP2 Facilitates Cardiac Adaptation in Chronic Heart Failure.
Alternate Accession IDs
E-GEOD-52797Sample Metadata Fields
Specimen part
Description
Transcriptional profiling of murine dendritic cells stimulated with LPS and IFNg after shRNA knockdown of redox regulators. Overall design: shRNA targeting redox regulators were delivered to bone marrow derived dendritic cells. Cells were stimulated with LPS and IFNg prior to transcriptional profili ...See More
Publication Title
Nitric Oxide Engages an Anti-inflammatory Feedback Loop Mediated by Peroxiredoxin 5 in Phagocytes.
Alternate Accession IDs
GSE115553Sample Metadata Fields
Specimen part, Treatment, Subject
Description
We performed a genome-scale CRISPR screen in a KRAS-mutant pancreatic cancer cell line treated with the MEK inhibitor trametinib, and found that loss of the transcriptional repressor CIC confers resistance to MEK inhibition. We determined that CIC loss also confers resistance to MEK or BRAF inhibiti ...See More
Publication Title
ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition.
Alternate Accession IDs
GSE78519Sample Metadata Fields
No sample metadata fields
Description
Transfection of dsDNA into many mammalian cell types indues the production of type I interferons and interferon-stimulated genes. We performed an siRNA screen to identify genes involved in this innate immune response, and identified Abcf1.
Publication Title
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Alternate Accession IDs
E-GEOD-42803Sample Metadata Fields
Specimen part
Description
CD8+ T cells can be reprogrammed for better persistence and robust effector function in TME. By performing an in vivo pooled CRISPR-Cas9 mutagenesis screening of metabolism-associated factors, we identify Regnase-1 as a major negative regulator of antitumor responses, whose deficiency results in dra ...See More
Publication Title
Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy.
Alternate Accession IDs
E-GEOD-137016Sample Metadata Fields
Specimen part
Description
We used microarrays to determine which genes are upregulated by IFNbeta stimulation in 293T cells.
Publication Title
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Alternate Accession IDs
E-GEOD-42802Sample Metadata Fields
Specimen part, Cell line, Treatment
Description
To understand the molecular curcuits perturbed by BET bromodoman inhibtion we obtained gene expression profiling of five DLBCL cell lines, SU-DHL6, OCI-Ly1, OCI-Ly4, Toledo and HBL-1, which were treated with either 500nM JQ1 or DMSO for 0,2,6,12,24 and 48hr.
Publication Title
Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.
Alternate Accession IDs
E-GEOD-45630Sample Metadata Fields
Specimen part, Cell line, Treatment, Time
Description
The five DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent ph ...See More
Publication Title
SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas.
Alternate Accession IDs
E-GEOD-43510Sample Metadata Fields
Specimen part, Cell line, Treatment, Time
Description
This SuperSeries is composed of the SubSeries listed below.
Publication Title
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Alternate Accession IDs
E-GEOD-61022Sample Metadata Fields
Specimen part, Cell line, Treatment, Time
Description
The two DLBCL cell lines were treated with R406 to assess the signature of SYK inhibition. In previous studies, R406 decreased the proliferation and induced apoptosis of these surface Ig+ cell lines. In the previous studies, R406 inhibited the autophosphorylation of SYK 525/526 and SYK-dependent pho ...See More
Publication Title
SYK inhibition modulates distinct PI3K/AKT- dependent survival pathways and cholesterol biosynthesis in diffuse large B cell lymphomas.
Alternate Accession IDs
E-GEOD-34176Sample Metadata Fields
Specimen part, Cell line, Treatment