Filters
Organism
Technology
Platforms
Description
We generated a gene replacement allele of the E-cadherin locus that express an N-cadherin-GFP fusion in ES cells. Expression profiles of homozygous and heterozygous knock-in ES cells were analyzed in comparison to wt ES cells.
Publication Title
Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency.
Alternate Accession IDs
E-GEOD-42008Sample Metadata Fields
No sample metadata fields
Description
We demonstrate that expression of key markers of keratinocyte differentiation is suppressed by exposure to sodium arsenite. Folate deficiency exacerbates this effect. In addition, cancer-related cell movement genes, and growth and proliferation genes are altered. Several redox-sensitive transcrip ...See More
Publication Title
Folate deficiency enhances arsenic effects on expression of genes involved in epidermal differentiation in transgenic K6/ODC mouse skin.
Alternate Accession IDs
E-GEOD-8733Sample Metadata Fields
No sample metadata fields
Description
ISCOM vaccines induce a balanced Th1/Th2 response and cytotoxic T lymphocytes. The adjuvant component, ISCOM-Matrix, consists of purified saponin fractions, cholesterol and phospholipids. The mode of action for the ISCOM-Matrix is known to some extent but still we lack knowledge of important segment ...See More
Publication Title
Global transcriptional response to ISCOM-Matrix adjuvant at the site of administration and in the draining lymph node early after intramuscular injection in pigs.
Alternate Accession IDs
E-GEOD-36306Sample Metadata Fields
Sex, Age, Specimen part, Treatment
Description
Loss of immune function and an increased incidence of myeloid leukemia are two of the most clinically significant consequences of aging of the hematopoietic system. To better understand the mechanisms underlying hematopoietic aging, we evaluated the cell intrinsic functional and molecular properties ...See More
Publication Title
Cell intrinsic alterations underlie hematopoietic stem cell aging.
Alternate Accession IDs
E-GEOD-4332Sample Metadata Fields
No sample metadata fields
Description
The tetracycline antibiotics are widely used in biomedical research as mediators of inducible gene expression systems. Despite many known effects of tetracyclines on mammalian cells -- including inhibition of the mitochondrial ribosome -- there have been few reports on potential off-target effects a ...See More
Publication Title
Doxycycline alters metabolism and proliferation of human cell lines.
Alternate Accession IDs
E-GEOD-45029Sample Metadata Fields
Specimen part, Cell line, Treatment
Description
We report the generation of induced oligodendrocyte precursor cells (iOPCs) by direct lineage conversion. Forced expression of the three transcription factors Sox10, Olig2 and Zfp536 was sufficient to convert mouse and rat fibroblasts into iOPCs with morphologies and gene expression signatures that ...See More
Publication Title
Generation of oligodendroglial cells by direct lineage conversion.
Alternate Accession IDs
E-GEOD-40421Sample Metadata Fields
Specimen part
Description
We used microarrays to detail the global program of gene expression underlying Parkinson's disease
Publication Title
A genomic pathway approach to a complex disease: axon guidance and Parkinson disease.
Alternate Accession IDs
E-GEOD-7621Sample Metadata Fields
No sample metadata fields
Description
In a randomized controlled dietary intervention study, we compared a diet enriched in polyunsaturated fatty acids (PUFA) with a diet enriched in saturated fatty acids (SFA) for influence on abdominal subcutaneous adipose tissue gene expression. We studied young lean adults; 11 women and 25 men. Ther ...See More
Publication Title
Overfeeding polyunsaturated and saturated fat causes distinct effects on liver and visceral fat accumulation in humans.
Alternate Accession IDs
E-GEOD-43642Sample Metadata Fields
Sex, Age, Specimen part, Treatment, Subject, Time
Description
Groucho related gene 5 (GRG5) is a multifunctional protein that has been implicated in late embryonic and postnatal mouse development. Here, we describe a previously unknown role of GRG5 in early developmental stages by analyzing its function in stem cell fate decisions. By both loss and gain of fun ...See More
Publication Title
Groucho related gene 5 (GRG5) is involved in embryonic and neural stem cell state decisions.
Alternate Accession IDs
GSE107068Sample Metadata Fields
Cell line, Subject
Description
PBMC from house dust mite (HDM) sensitized atopics were cultured in the presence or absence of HDM extract for 24 hours.
Publication Title
Distinguishing benign from pathologic TH2 immunity in atopic children.
Alternate Accession IDs
E-GEOD-70760Sample Metadata Fields
No sample metadata fields