GSE37655

Gene expression alteration by macrophage depletion in IKK mutant mice

Mus musculus
3 Downloadable Samples
Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description
We generated Ikk-KA/KA knock-in mice (KA/KA), in which an ATP binding site of Ikk Lys 44 was replaced by alanine. The knock-in mice develop severe skin lesions and begin to die after 6 to 10 months. We also found lung SCCs in some of the mice. To study lung SCC development, we stabilize the skin condition by crossing KA/KA with Lori.Ikk transgenic mice to generate KA/KA-Lori.Ikk mice, which 100% spontaneously developed lethal lung SCC at 4 to 6 months of age.
PubMedID
23597566
Publication Title
The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas.
Total Samples
3
Submitter’s Institution
Authors
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Source Repositories
Gene Expression Omnibus (GEO)
Alternate Accession IDs
E-GEOD-37655

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