Description
Identification of differentially regulated genes in the PU.1 Q202L point mutant that disrupts association with c-Jun. The goal was to identify PU.1 target genes that depend on the co-activation of PU.1 by c-Jun. Mice have normal ST-HSC but lack normal GMP, so a population of GMP-like cells (lin- Sca-1+ c-kit- FcgRII/IIIhi CD34intermediate) was used in the mutant.