Impact of KLF2 expression on T cell genetic program

On triggering of the T cell receptor CD8 T lymphocytes downregulate expression of the transcription factor KLF2. KLF2 expression remains low as these cells differentiate to Cytotoxic T lymphocytes (CTL) but may be re-expressed depending on the local environmental signals.

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Preston GC, Feijoo-Carnero C, Schurch N, Cowling VH, Cantrell DA