Modulation of microglia-mediated amyloid-beta clearance with nanoformulated polyphenol through the SIRT1-LDLR pathway

Light-controlled in situ synthesis of DNA microarrays (Affymetrix GeneChip Mouse Genome 430 2.0) were performed to determine the altered gene expression. Affymetrix algorithm and multiple analysis comparison software were used for assessing gene expression differences, and mRNAs that increased or decreased in the brains of NP(-M)-treated mice relative to that in the brains of Blank-NP-treated mice were identified.

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